Jelena Korać Prlić

Jelena Korać Prlić, izv. prof. dr. sc. 



     Jelena Korać Prlić je izvaredna profesorica zaposlena  na Katedri za imunologiju i medicinsku genetiku Medicinskog fakulteta, Sveučilišta u Splitu od 2013. godine gdje sudjeluje u znanstvenoj i nastavnoj aktivnosti katedre. Diplomirala je na dva fakulteta, 2007. na Prirodoslovno-matematičkom fakultetu, smjer Molekularna biologija, te 2011. na Farmaceutsko-biokemijskom fakultetu, smjer Medicinska biokemija. Doktorat znanosti stekla je pod mentorstvom prof. dr. Ivana Đikića radeći na Medicinskom fakultetu Sveučilišta u Splitu te kao gostujući student na Medicinskom fakultetu, Goethe sveučilišta u Frankfurtu. Godine 2013. obranila je doktorsku disertaciju s temom „Uloga proteina optineurina u autofagiji proteinskih nakupina u neurodegenerativnim bolestima“. Nakon doktorata radila je kao poslijedoktorand na projektu prof. dr. Janoša Terzića s temom ”Uloga upale u razvoju raka mokraćnog mjehura“ (HRZZ).
     Trenutačno istražuje molekularne i stanične mehanizme upale odgovorne i utjecaj imunoloških stanica na razvoj mokraćnog mjehura. Istraživanje se radi na miševima kojima nedostaje točno određeni gen bitan u procesu upale (tzv. knock-out i conditional knock-out miševi), te se koristi BBN mišji model za rak mokraćnog mjehura. Voditeljica je HRZZ Uspostavnog projekta "Imunomodulacijski učinci mastocita i eozinofila u mikrookolišu tumora mokraćnog mjehura".
 

HRZZ projekt "Imunomodulacijski učinci mastocita i eozinofila u mikrookolišu tumora mokraćnog mjehura"

   Jelena Korać Prlić is an Associate Professor at the Department of Immunology and Medical Genetics, School of Medicine, the University of Split since 2013. where she participates in research and teaching. She graduated in Molecular biology from the Faculty of Science, the University of Zagreb in 2007. and Medical Biochemistry at Faculty of Pharmacy and Biochemistry, University of Zagreb, in 2011. She received her PhD in 2013. at the School of Medicine, the University of Split, under the supervision of Prof. Ivan Đikić with PhD thesis “The role of optineurin in autophagic clearance of protein aggregates in neurodegenerative diseases”. During her PhD, she was visiting student at the Medical Faculty of the Goethe University, Frankfurt. After her PhD, she worked as a postdoc on the project of prof. Dr Janoš Terzić "The role of inflammation in the development of bladder cancer" (HRZZ).
     Her research interests are focused on understanding the molecular and cellular mechanisms of inflammation-induced bladder cancer development and the role of immune cells in that. Research is done on BBN mice model for bladder cancer using knock-out and conditional knock-out mice models targeting genes involved in inflammation. Currently, she is the leader of the HRZZ project " Immunomodulatory role of mast cells and eosinophils in bladder cancer microenvironment".

HRZZ Project "Immunomodulatory role of mast cells and eosinophils in bladder cancer microenvironment"

Publications:

Franković L, Degoricija M, Gabela I, Vilović K, Korac-Prlic, J (2025) Pro-tumorigenic effect of continuous cromolyn treatment in bladder cancer. Int. J. Mol. Sci. 26, 1619. doi.org/10.3390/ijms26041619 Knezović D, Milić Roje B, Vilović K, Franković L, Korac-Prlic J, Terzić J. (2024) MyD88 Signaling Accompanied by Microbiota Changes Supports Urinary Bladder Carcinogenesis. Int J Mol Sci. Jun 29;25(13):7176. doi: 10.3390/ijms25137176 Viculin J, Degoricija M, Vilović K, Gabela I, Franković L, Vrdoljak E, Korac-Prlic J (2023) Elevated Tumor Cell-Intrinsic STING Expression in Advanced Laryngeal Cancer. Cancers (Basel). 2023 Jul 5;15(13):3510. doi: 10.3390/cancers15133510 Kunac N, Degoricija M, Viculin J, Omerović J, Terzić J, Vilović K, Korac-Prlic J (2022) Activation of cGAS-STING Pathway Is Associated with MSI-H Stage IV Colorectal Cancer. Cancers (Basel). 2022 Dec 30;15(1):221. doi: 10.3390/cancers15010221. Korac-Prlic J*, Degoricija M*, Vilovic K, Vujevic S, Terzic J (2020) BBN-driven urinary bladder cancer mouse model, Methods in Cell Biology, 2021;163:77-92. doi: 10.1016/bs.mcb.2020.10.020. (*equal contribution). Korac-Prlic J, Degoricija M, Vilovic K, Ivanisevic T, Haupt B, Frankovic L, Grivennikov S, Terzic J (2020) Stat3 signalling is essential for bladder cancer progression. Cancer Letters, 490:89-99, doi: 10.1016/j.canlet.2020.06.018. Degoricija M, Korac-Prlic J, Vilovic K, Ivanisevic T, Haupt B, Palada V, Petkovic M, Karaman I, Terzic J (2019): The dynamics of the inflammatory response during BBN-induced bladder cancerogenesis in mice. Journal of Translational Medicine, 17 (2019), 1; 394, doi: 10.1186/s12967-019-02146-5. Zupančič D*, Korac-Prlic J*, Erdani Kreft M, Frankovic L, Vilovic K, Jeruc J, Romih R, Terzić J (2020) Vitamin A enriched diet diminishes early urothelial carcinogenesis. Cancers, 12(7):1712, doi: 10.3390/cancers12071712. (*equal contribution) Leznicki P*, Korac-Prlic J*, Kliza K, Husnjak K, Nyathi Y, Dikic I, High S (2015) SGTA binding to Rpn13 selectively modulates protein quality control. J Cell Sci. 128(17):3187-96. doi: 10.1242/jcs.165209. (*equal contribution) Aguileta MA, Korac J, Durcan TM, Trempe JF, Haber M, Gehring K, Elsasser S, Waidmann O, Fon EA, Husnjak K (2015) The E3 ubiquitin ligase parkin is recruited to the 26 S proteasome via the proteasomal ubiquitin receptor Rpn13. J Biol Chem. 290(12):7492-505. doi: 10.1074/jbc.M114.614925. Degoricija M, Situm M, Korac J, Miljkovic A, Matic K, Paradzik M, Marinovic Terzic I, Jeroncic A, Tomic S, Terzic J (2014) High NF-κB and STAT3 activity in human urothelial carcinoma: a pilot study. World J Urol. 32(6):1469-75. doi: 10.1007/s00345-014-1237-1. Korac J, Schaeffer V, Kovacevic I, Clement AM, Jungblut B, Behl C, Terzic J, Dikic I (2013) Ubiquitin-independent function of optineurin in autophagic clearance of protein aggregates. J Cell Sci. 126(Pt 2):580-92. doi: 10.1242/jcs.114926. Zizak M, Chen T, Bartonicek D, Sarker R, Zachos NC, Cha B, Kovbasnjuk O, Korac J, Mohan S, Cole R, Chen Y, Tse CM, Donowitz M (2012) Calmodulin kinase II constitutively binds, phosphorylates, and inhibits brush border Na+/H+ exchanger 3 (NHE3) by a NHERF2 protein-dependent process. J Biol Chem. 287(16):13442-56. doi: 10.1074/jbc.M111.307256. Wild P, Farhan H, McEwan DG, Wagner S, Rogov VV, Brady NR, Richter B, Korac J, Waidmann O, Choudhary C, Dötsch V, Bumann D, Dikic I (2011) Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth. Science. 333(6039):228-33 doi: 10.1126/science.1205405. Barisic M*, Korac J*, Pavlinac I*, Krzelj V*, Marusic E, Vulliamy T, Terzic J (2005) Characterization of G6PD deficiency in southern Croatia: description of a new variant, G6PD Split. J Hum Genet. 50(11):547-9. doi: 10.1007/s10038-005-0292-2. (*equal contribution)

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