English
The title of HRZZ research project:
Biomarker discovery using multi-omics profiles in Hashimoto's thyroiditis
Acronym of the project: HT-OMICS
Project duration: 31.12.2023. - 30.12.2027.
Principal Investigator: prof. dr. sc. Vesna Boraska Perica
Project collaborators:
prof. dr. sc. Ante Punda,
doc. dr. sc. Ana Barić Žižić,
doc. dr. sc. Vesela Torlak Lovrić,
dr. sc. Dean Kaličanin,
mr. sc. Maja Cvek,
Marko Vuletić, dr.med,
Vanna Žnidar, univ. mag. math,
prof. dr. sc. Eleftheria Zeggini,
dr. sc. So-Youn Shin
Project summary:
Hashimoto's thyroiditis (HT) is the most common autoimmune disease today. The molecular mechanisms underlying the disease are still not sufficiently known, therefore, this project is aimed at discovering new knowledge related to the molecular and biological pathways related to HT. This project is a continuation of the previous HRZZ Installation Grant, in which we formed the CRO-HT biobank of biological samples and phenotypes for 500 subjects with HT and performed a GWAS of this disease. In the meantime, we have collected another 200 control subjects. In the proposed project, through objective 1 (O1 Expansion of the CROHT biobank), we plan to include an additional 200 subjects with HT and to genotype their genome. Also, we plan to measure and analyze protein and metabolic markers through objectives 2 (O2 Proteomic profiling of HT for biomarker discovery) and 3 (O3 Metabolomic profiling of HT for biomarker discovery). Through these objectives, we will try to: a) Identify differentially expressed proteome/metabolome biomarkers between HT cases and control subjects and examine omics profiles with HT disease severity, (b) Assess associations between significant biomarkers and clinical features of HT, (c) Integrate all available omics data (whole genome genotypes, proteome and metabolome) to gain deeper insights in disease manifestation, (d) Examine causal relationships between significant biomarkers (metabolites and proteins) and HT using Mendelian randomization. Through the last objective 4 (O4 Evaluation of the role of intestinal wall permeability with HT), we plan to measure and analyse the protein zonulin, which is currently the only measurable marker of intestinal permeability. With the proposed comprehensive research, we strive to produce broader knowledge on molecular pathophysiology, disease biomarkers, predictive models, preventive medicine, and potential therapeutic, personalised approaches for patients with HT.
Conference Abstracts:
Vanna Žnidar, Dean Kaličanin, Ana Barić, Marko Vuletić, Sanda Sladić, Vesela Lovrić Torlak, Maja Cvek, Ante Punda, Vesna Boraska Perica. “Inflammatory Signatures in Hashimoto’s Thyroiditis: A Proteomic Approach to Disease Progression and Treatment Effects”. European Human Genetics Conference (ESHG), 24-27 May 2025, Milan, Italy.
Vanna Žnidar, univ.mag.math. and mentor prof.dr.sc. Vesna Boraska Perica - Poster
Educations:
Vanna Žnidar,
univ.mag.math., participated in the
Volos Summer School of Human Genetics 2025, a four-day intensive course held at the University of Thessaly, organized by the University of Thessaly and Helmholtz Munich, the program focused on advanced methods in human genetic research and analysis,
https://volossummerschool.info/.
Vanna Žnidar and her team at Volos Summer School of Human Genetics 2025.
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