Translacijsko istraživanje neuroplastičnosti disanja i učinka intermitentne hipoksije u anesteziji i spavanju



Translacijsko istraživanje neuroplastičnosti disanja i učinka intermitentne hipoksije u anesteziji i spavanju

Projekt Hrvatske zaklade za znanost
voditelj: prof. dr. sc. Zoran Đogaš
Trajanje: 01.09.2014. - 31.12.2018.

Our understanding of the brain control of breathing and awareness of the widespread prevalence of obstructive sleep apnea syndrome (OSAS) have both increased in the last decade or two. The link between the two is poorly understood. There is growing evidence that OSAS contributes to the initiation and progression of hypertension, heart failure, cardiac ischemia, stroke and cognitive decline. Chronic sympathetic activation resulting in elevated sympathetic nerve activity and cardio-respiratory sensitivity to hypoxia appears to be important. Still, the exact mechanisms underlying the link between OSA and cardiovascular and neurophysiologic disturbances are not completely known. Intermittent hypoxia (IH) in experimental animals can mimic periods of repeated apneas seen in OSAS patients. Exposure to repeated bouts of hypoxia in human leads to increased sympathetic activity, whilst intermittent hypoxia in experimental animals evokes increases in phrenic and sympathetic nerve activities. The proposed study will examine the role of neurotransmitters/neuromodulators (e.g. serotonin and opioids) in evoking sympathetic long-term facilitation using anesthetized animal model of IH. The only way to understand complex pathophysiological interactions in OSAS patients is to use translational and multidisciplinary approach, as proposed in this project. Our focus in the human studies is to study neurophysiologic (brain motor control, control of breathing, neurographic features of peripheral nerves, and muscle sympathetic activity) function in OSAS patients and the links to metabolic, stress, and cognitive parameters. Preliminary data from pilot studies suggest it is possible to achieve the new findings using this novel approach. We will also study longitudinal therapeutic effects of the gold standard therapy in OSAS such as the overnight use of continuous positive airway pressure (CPAP) devices in Split Sleep Cohort of patients, which we plan to form during the work on this project. 

Team members:
(Master's degree) Ivana Pavlinac Dodig,(Doctor's degree) Maja Rogić,(Doctor's degree) Renata Pecotić,(Professor) Maja Valić,(Master's degree) Linda Lušić,(Professor) Sunčana Kukolja Taradi,(Doctor's degree) Mladen Carev,(Doctor's degree) Tina Tičinović Kurir,(Master's degree) Joško Božić,(Master's degree) Mario Mihalj,(Professor) Goran Račić,(Doctor's degree) Nenad Karanović,(Doctor's degree) Toni Brešković,(Master's degree) Marin Šimunić,(Professor) Dušan Šuput
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