Neurokardiologija
LABORATORIJ ZA EKSPERIMENTALNU NEUROKARDIOLOGIJU
Voditeljica laboratorija: izv. prof. dr. sc. Natalija Filipović (publikacije)
Aktivni članovi istraživačke grupe:
prof. dr. sc. Ivica Grković, osnivač i bivši voditelj laboratorija (
publikacije)
prof. dr. sc. Katarina Vukojević (
publikacije)
dr. sc. Ivan Agnić (
publikacije)
dr. sc. Ana Vuica (
publikacije)
dr. sc. Benjamin Benzon
dr. sc. Vana Košta
Danica Boban, dr. med.
Marija Jurić, dr. med.
Ivana Šolić, dr. med.
Marija Vitlov Uljević, mag. pharm.
Martina Luetić, dr. med.
Edita Dražić-Maras, dr. med.
Ivan Brdar, dr. med.
Marjan Urlić, dr. med.
Leo Jerčić, dr. med. vet.
Igor Roje, dr. med.
Ivan Šustić, dr. med.
Diana Bajo, dr. med.
Josipa Domazet-Bugarin, dr. med.
Adela Arapović, dr. med.
Maja Dražić, dr. med.
Genia Kretzschmar, dr.med.
Maximilian Grobe, dr.med.
Silvia Dužević, dr.med.
Laboratorij za neurokardiologiju bavi se istraživanjima autonomne inervacije, s posebnim naglaskom na srčanu inervaciju; kako u fiziološkim uvjetima, tako i u patološkim stanjima ozljede izazvane infarktom miokarda i metaboličkim poremećajima.
Publikacije:
Urlić, Marjan, Urlić, Ivanka,
Urlić, Hrvoje, Mašek, Tomislav,
Benzon, Benjamin,
Vitlov Uljević, Marija,
Vukojević, Katarina,
Filipović, Natalija (2020): Effects of Different n6/n3 PUFAs Dietary Ratio on Cardiac Diabetic Neuropathy. Nutrients
12: 2761.
Milardović, Ivana,
Vitlov Uljević, Marija,
Vukojević, Katarina, Kostić, Sandra,
Filipović, Natalija (2020): Renal expression of sigma 1 receptors in diabetic rats. Acta histochem. 122:151580.
Filipović, Natalija, Ivana Bočina, Ivana Restović,
Maximilian Grobe,
Genia Kretzschmar, Nives Kević, Tomislav Mašek,
Marija Vitlov Uljević,
Marija Jurić,
Katarina Vukojević, Mirna Saraga-Babić,
Ana Vuica (2020): Ultrastructural characterization of vitamin D receptors and metabolizing enzymes in the lipid droplets of the fatty liver in rat. Acta histochem. 122: 151502.
Luetić, Martina,
Vitlov Uljević, Marija, Mašek, Tomislav,
Benzon, Benjamin,
Vukojević, Katarina,
Filipović, Natalija (2020): PUFAs supplementation affects the renal expression of pannexin 1 and connexins in diabetic kidney of rats. Histochem Cell Biol. 153: 165-175.
Vitlov Uljević, Marija, Starčević, Kristina, Mašek, Tomislav, Bočina, Ivana, Restović, Ivana, Kević, Nives, Racetin, Anita, Kretzschmar, Genia, Grobe, Maximilian, Vukojević, Katarina, Saraga-Babić, Mirna, Filipović, Natalija (2019): Dietary DHA/EPA supplementation ameliorates diabetic nephropathy by protecting from distal tubular cell damage. Cell and tissue research. 378: 301-317.
Jerčić, Leo, Kostić, Sandra,
Vitlov Uljević, Marija, Vukušić Pušić, Tanja,
Vukojević, Katarina, Filipović, Natalija (2019): Sigma-1 receptor expression in DRG neurons during a carrageenan-provoked inflammation. Anatomical record-advances in integrative anatomy and evolutionary biology. 302: 1620-1627.
Vitlov Uljević, Marija, Bočina, Ivana, Restović, Ivana, Kunac, Nenad, Mašek, Tomislav;
Kretzschmar, Genia,
Grobe, Maximilian, Šarić, Mia,
Vukojević, Katarina, Saraga-Babić, Mirna,
Filipović, Natalija (2018): Reabsorption in the proximal tubuli – an ultrastructural evidence for a novel aspect of renal VEGF trafficking. Cell and tissue research. 374: 189-201
Grobe, Maximilian; Kretzschmar, Genia; Vuica, Ana; Filipović, Natalija (2018): Expression of VDR in the superior cervical ganglia of rats. Biotechnic & histochemistry. 93: 320-327
Agnić, Ivan,
Filipović, Natalija,
Vukojević, Katarina, Saraga-Babić, Mirna,
Grković, Ivica (2018): Isoflurane postconditioning influences dynamics of infarct healing in rats. Biotechnic & histochemistry. 93: 354-363
Baković, Marija,
Filipović, Natalija, Ferhatović Hamzić, Lejla, Kunac, Nenad, Zdrilić, Elena, Vitlov Uljević, Marija, Kostić, Sandra, Puljak, Livia,
Vukojević, Katarina (2018): Changes in neurofilament 200 and tyrosine hydroxylase expression in the cardiac innervation of diabetic rats during ageing. Cardiovascular pathology 32: 38-43
Jerić, Milka,
Vukojević, Katarina,
Vuica, Ana,
Filipović, Natalija (2017): Diabetes mellitus influences the expression of NPY and VEGF in neurons of rat trigeminal ganglion. Neuropeptides 62: 57-64
Vuica, Ana,
Katarina Vukojević, Lejla Ferhatović Hamzić,
Milka Jerić, Livia Puljak,
Ivica Grković,
Natalija Filipović (2016): Expression pattern of CYP24 in liver during ageing in long-term diabetes. Acta Histochemica A Journal of Structural Biochemistry, Cell and Tissue Imaging 118: 486-495
Agnić, Ivan,
Natalija Filipović,
Katarina Vukojević, Mirna Saraga-Babić,
Marija Vrdoljak,
Ivica Grković (2015): Effects of isoflurane post-conditioning on chronic phase of ischemia-reperfusion heart injury in rats. Cardiovascular pathology 24: 94-101
Filipović, Natalija, Tomislav Mašek,
Ivica Grković (2015): Expression of nestin in superior cervical ganglia of rats is influenced by gender and gonadectomy. Journal of chemical neuroanatomy 63: 6-12
Jerić, Milka,
Ana Vuica, Matija Borić, Livia Puljak, Antonia Jeličić Kadić,
Ivica Grković,
Natalija Filipović (2015): Diabetes mellitus affects activity of calcium/calmodulin-dependent protein kinase II alpha in rat trigeminal ganglia. Journal of chemical neuroanatomy 64-65: 12-19
Vuica, Ana, Lejla Ferhatović Hamzić,
Katarina Vukojević,
Milka Jerić, Livia Puljak,
Ivica Grković,
Natalija Filipović (2015): Ageing and a long-term diabetes mellitus increase expression of 1 α-hydroxylase and vitamin D receptors in the rat liver. Experimental gerontology 72: 167-176
Agnić, Ivan,
Katarina Vukojević, Mirna Saraga-Babić,
Natalija Filipović,
Ivica Grković (2014): Isoflurane post-conditioning stimulates the proliferative phase of myocardial recovery in an ischemia-reperfusion model of heart injury in rats. Histology and histopathology 29: 89-99
Filipović, Natalija,
Marija Vrdoljak,
Ana Vuica,
Milka Jerić, Antonia Jeličić Kadić, Toni Utrobičić, Tomislav Mašek,
Ivica Grković (2014): Expression of PTHrP and PTH/PTHrP receptor 1 in the superior cervical ganglia of rats. Neuropeptides 48: 353-359
Filipović, Natalija, Leona Žuvan, Tomislav Mašek, Ružica Tokalić,
Ivica Grković (2014): Gender and gonadectomy influence on neurons in superior cervical ganglia of sexually mature rats. Neuroscience letters 563: 55-60
Banožić, Adriana,
Ivica Grković, Damir Sapunar, Livia Puljak (2014): Behavioral changes following experimentally-induced acute myocardial infarction in rats. International heart journal. 55: 169-177
Baković, Marija, Marina Jurić Paić, Elena Zdrilić,
Katarina Vukojević, Lejla Ferhatović, Ana Marin,
Natalija Filipović,
Ivica Grković, Livia Puljak (2013) Changes in cardiac innervation during maturation in long-term diabetes. Experimental gerontology. 48: 1473-1478
Filipović, Natalija, Lejla Ferhatović, Ivana Marelja, Livia Puljak,
Ivica Grković (2013): Increased vitamin D receptor expression in dorsal root ganglia neurons of diabetic rats. Neuroscience letters 549: 140-145
Marinović Guić, Maja, Branka Runtić, Vana Košta, Jure Aljinović,
Ivica Grković (2013): Age-related changes of neurochemically different subpopulations of cardiac spinal afferent neurons in rat. Experimental gerontology. 48: 774-777
Košta, Vana, Maja Marinović Guić, Jure Aljinović, Ana Čarić,
Ivica Grković (2011): The influence of exercise on morphological and neurochemical properties of neurons in rat nodose ganglia. Neuroscience letters 490: 36-40
Aljinović, Jure,
Katarina Vukojević, Vana Košta, Maja Marinović Guić, Mirna Saraga-Babić,
Ivica Grković (2010): Histological differences in healing following experimental transmural infarction in rats. Histology and histopathology. 25: 1507-1517
Košta, Vana, Maja Marinović Guić, Jure Aljinović, Damir Sapunar,
Ivica Grković (2010): Immunohistochemical characteristics of neurons in nodose ganglia projecting to the different chambers of the rat heart. Autonomic neuroscience: basic & clinical 155: 33-38
Marinović Guić, Maja, Vana Košta, Jure Aljinović, Damir Sapunar,
Ivica Grković (2010): Characterization of spinal afferent neurons projecting to different chambers of the rat heart. Neuroscience letters 469: 314-318
Iz zbirke fotografija laboratorija:
Dopaminergic neurons in substantia nigra of rat. (G. Kretzschmar and M. Grobe)
Astrocytes (green; gfap) and microglia (red; iba1), in hippocampus of rat (nuclei are stained blue). (G. Kretzschmar and M. Grobe)
Lipid droplets in renal proximal tubular cells, stained by Sudan-red method. (N. Filipović)
Infarkt miokarda štakora tijekom cijeljenja. Nestin - marker nezrelih stanica (zeleno), alfa glatki aktin - aSMA (crveno), jezgre su obojene plavo. (N. Filipović)
Infarkt miokarda štakora tijekom cijeljenja. Nestin - marker nezrelih stanica (zeleno), alfa glatki aktin - aSMA (crveno), jezgre su obojene plavo. (N. Filipović i M. Vrdoljak)
Gornji cervikalni ganglij štakora. Neuropeptid y u neuronima (zeleno), calretinin u presinaptičkim živčanim završecima (crveno). (N. Filipović)
Pgp9.5 u živčanim završecima u miokardu štakora (zeleno). (N. Filipović, M. Vrdoljak i D. Jakus)
Stelatne stanice u jetri štakora imunoreaktivne na gfap (zeleno), jezgre su obojene plavo. (A. Vuica)
Neurofilament 200 kDa (crveno) u ventralnom rogu kralježnične moždine ljudskog embrija starog 9 tjedana, jezgre su obojene plavo. (N. Filipović)
Receptori paratireoidnog hormona u membranama kardiomiocita štakora (zeleno), jezgre su obojene plavo. (N. Filipović)
Neurofilament 200 kDa (crveno) u trigeminalnom gangliju štakora. (N. Filipović)
Izolektin b4 (zeleno), vezan u neuronima trigeminalnog ganglija štakora. (M. Jerić)
CGRP (crveno) u neuronima trigeminalnog ganglija štakora. (N. Filipović)
s100 (zeleno) u satelitskim stanicama gornjeg cervikalnog ganglija štakora. (N. Filipović)
Kolin acetil transferaza u presinaptičkim živčanim završecima u gornjem cervikalnom gangliju štakora (crveno). (N. Filipović)
NeuN u neuronima trigeminalnog ganglija štakora. (N. Filipović)
Parasimpatički neuroni u srži nadbubrežne žlijezde štakora. Za razliku od kromafinih stanica, nisu imunoreaktivni na tirozin-hidroksilazu (zeleno), jezgre su obojene plavo. (N. Filipović)
Receptori za napredne produkte glikozilacije - RAGE - u membranama stanica jetre štakora (crveno), jezgre su obojene plavo. (N. Filipović)
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