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Assoc Prof Ozren Polašek
 

The 10,001 Dalmatians project is currently the best ranked research project in the field of Biomedicine.

The main objective of this program is to create a comprehensive resource for the study of genetic, environmental and social determinants of health and diseases with emphasis on chronic diseases which are the leading cause of death in Croatia and other developed countries.

 Visual mapping of different research locations and time periods in Croatia
 

Previous research results of this program have helped in understanding the metabolism of uric acid, blood pressure levels, lung function, eye traits, blood lipid levels, onset of menarche and menopause, sleep regulation, smoking and levels of glycans, based on the genome-wide association study. The main approach of this method is the analysis of the association of a large number of genetic markers with the observed trait. By using this method,   the scientists involved in the 10,001 Dalmatians program put Croatia on the 20th place in the world for the use of genome-wide analysis (Rosenberg NA, et al. Genome - wide association studies in diverse populations. Nat Rev Genet. 2010; 11:356-66).

Active projects

 

Group members
Assoc Prof Ozren Polašek, PhD, lead researcher [CV]

Assist Prof Ivana Kolčić, researcher [CV]
Mirna Kirin, PhD, postdoc  [CV] 
Andrea Gelemanović, doctoral student  [CV]
Ana Miljković, doctoral student  [CV]
Ajka Relja, doctoral student [CV]

Foto gallery 

Future directions
Conduct further GWAS and post-GWAS analysis on existing data and expand the existing resource by re-collecting the data from the existing participants. Secure funding for sequencing and strengthen capacities for analysis.

 

Selected publications and doctoral theses  

Interests and topics: GWAS, gene network, gene pathway, biobank, genetics, isolate, population