Laboratory for experimental pharmacology
Our research has focused on the effects of drugs and the biological effects of food ingredients, especially wine and its constituents.
Laboratory for experimental pharmacology
Head of research group
Marko Grahovac, MD
Research:
Research is carried out in the field of basic and clinical pharmacology. Non-clinical studies include in vitro experimental models of isolated heart and blood vessels, in vivo animal models, and biochemical analysis of various biological samples. Interventional studies in humans are in the field of cardiovascular physiology and pharmacology. The group has extensive experience in non-invasive measurements of hemodynamic parameters for the assessment of vascular function and analysis of blood samples for the cardiometabolic indicators. Our research has focused on the effects of drugs and the biological effects of food ingredients, especially wine and its constituents.
Projects:
Projects:
Biološki učinci vina: utjecaj vinifikacijske tehnologije, dealkoholizacije i starenja vina - BioWine
Lead researcher: prof. Mladen Boban, MD, PhD.
Funded by Croatian Science Foundation - HrZZ IP-2013-11-8652
Duration: 2014 - 2019
Funded by Croatian Science Foundation - HrZZ IP-2013-11-8652
Duration: 2014 - 2019
Izravni krvožilni učinci odabranih ekstrakata mediteranskih biljaka
Lead researcher: prof. Mladen Boban, MD, PhD.
Funded by Stella Mediterranea (sponsored research)
Duration: 2014
Duration: 2014
Lead researcher: prof. Mladen Boban, MD, PhD.
Funded by Ministry of Science and Education 2160547
Duration: 2007 - 2013
Funded by Ministry of Science and Education 2160547
Duration: 2007 - 2013
Lead researcher: prof. Mladen Boban, MD, PhD.
Funded by Ministry of Science and Education 216-2160547-0537
Duration: 2007 - 2013
Funded by Ministry of Science and Education 216-2160547-0537
Duration: 2007 - 2013
Farmakologija kardiovaskularnog sustava
Lead researcher: prof. Mladen Boban, MD, PhD.
Funded by croatian-slovenian bilateral collaborative programe
Duration: 2003 - 2008
Funded by croatian-slovenian bilateral collaborative programe
Duration: 2003 - 2008
Lead researcher: prof. Mladen Boban, MD, PhD.
Funded by croatian-slovenian bilateral collaborative project
Duration: 2002 - 2005
Funded by croatian-slovenian bilateral collaborative project
Duration: 2002 - 2005
Izvantjelesno očuvanje srca
Lead researcher: prof. Mladen Boban, MD, PhD.
Funded by Ministry of Science and Education 0216012
Duration: 2007 - 2013
Funded by Ministry of Science and Education 0216012
Duration: 2007 - 2013
Group members:
Marko Grahovac, MD, head of the Lab [CV]
prof. Mladen Boban, MD., PhD., lead researcher [CV]
assoc prof. Ivana Mudnić, MD., PhD., lead researcher [CV]
prof. Darko Modun, MD., PhD., lead researcher [CV]
assist. prof. Diana Gujinović, M.Pharm., PhD, lead researcher [CV]
Anamarija Dželalija, M.Pharm., PhD, postdoctoral student [CV]
Marin Mornar, MD, doctoral student [CV]
Ana Marijanović Ukić, M. Chem., professional associate [CV]
Jurica Nazlić, MD, associate [CV]
Foto album
Futre directions:
It is planned to continue research activity with the use of all described methods and models. The focus will continue to be on the research of cardiovascular and cardiometabolic effects of drugs and food ingredients under control and in various pathophysiological conditions (surgically induced myocardial infarction, ischemia-reperfusion injury, e.g.) Interventional studies in humans will be performed on healthy subjects, and on patients with targeted diagnoses. All this opens possibilities for collaboration with physicians of different specialties, as well as cooperation with the pharmaceutical and food industry.
Selected publications
Selected publications
Interests and topics: Cardiovascular pharmacology, wine, polyphenols, isolated heart, isolated blood vessels, arterial stiffness, endothelial function, oxidative stress.