Laboratory for experimental pharmacology
research in the field of basic and clinical pharmacology as well as experimental and humane pharmacology and physiology of cardiovascular apparatus.
Laboratory for experimental pharmacology
Head of research group:
prof. Mladen Boban and assoc. prof. Ivana Mudnić
prof. Mladen Boban and assoc. prof. Ivana Mudnić
Research:
Scope of group includes research in the field of basic and clinical pharmacology as well as experimental and humane pharmacology and physiology of cardiovascular apparatus.
Basic research is carried out in the pharmacological-analytical part of the Laboratory equipped for experiments on small animals and work on isolated organs, such as the heart and blood vessels, as well as analytical devices for determining the composition and antioxidant activity of various biological samples. Research are aimed to study of vasodilation, vasoconstriction, cardiomodulatory and antioxidant effects of drugs and food ingredients, with an emphasis on underlying mechanisms that can be investigated with different pharmacological tools.
In the second part of the Laboratory, equipped with devices for non-invasive hemodynamic measurements, studies are carried out on people, healthy volunteers or patients, with the aim of measuring arterial function parameters during pharmacological or some other intervention.
Basic research is carried out in the pharmacological-analytical part of the Laboratory equipped for experiments on small animals and work on isolated organs, such as the heart and blood vessels, as well as analytical devices for determining the composition and antioxidant activity of various biological samples. Research are aimed to study of vasodilation, vasoconstriction, cardiomodulatory and antioxidant effects of drugs and food ingredients, with an emphasis on underlying mechanisms that can be investigated with different pharmacological tools.
In the second part of the Laboratory, equipped with devices for non-invasive hemodynamic measurements, studies are carried out on people, healthy volunteers or patients, with the aim of measuring arterial function parameters during pharmacological or some other intervention.
Publications:
N. Režić-Mužinić, A. Mastelić, B. Benzon, A. Markotić, I. Mudnić, I. Grković I, M. Grga, AM. Milat, N. Ključević, M. Boban. Expression of adhesion molecules on granulocytes and monocytes following myocardial infarction in rats drinking white wine. PLoS ONE. 2018; 13(5): e0196842.
AM. Milat, I. Mudnić, I. Grković, N. Ključević, M. Grga, I. Jerčić, D. Jurić, D. Ivanković, B. Benzon, M. Boban. Effects of White Wine Consumption on Weight in Rats: Do Polyphenols Matter? Oxidative Medicine and Cellular Longevity. 2017; 8315803.
A. Jeroncic, G. Gunjaca, D. Budimir Mrsic, I. Mudnic, I. Brizic, O. Polasek, M. Boban. Normative equations for central augmentation index: assessment of inter-population applicability and how it could be improved. Scientific Reports. 2016; 6:27016.
G. Gunjaca, A. Jeroncic, D. Budimir, I. Mudnic, I. Kolcic, O. Polasek, I. Rudan, M. Boban. A complex pattern of agreement between oscillometric and tonometric measurement of arterial stiffness in a population-based sample. Journal of Hypertension. 2012; 30(1): 1444-1452.
I. Mudnic, D. Modun, V. Rastija, J. Vukovic, I. Brizic, V. Katalinic, B. Kozina, M. Medic-Saric, M. Boban. Antioxidative and vasodilatory effects of phenolic acids in wine. Food Chemistry. 2010; 119: 1205-1210.
M. Boban, D. Modun, I. Music, J. Vukovic, I. Brizic, I. Salamunic, A. Obad, I. Palada, Z. Dujić. Red wine induced modulation of vascular function: separating the role of polyphenols, ethanol, and urates. Journal of Cardiovascular Pharmacology. 2006; 47(5): 695-701.
V Katalinic, M. Milos, D. Modun, I. Music, M. Boban. Antioxidant effectiveness of selected wines in comparison with (+)-catechine. Food Chemistry. 2004; 86(4):593-600.