Laboratory for Neurocardiology

Laboratory for Neurocardiology

Head of laboratory: Associate professor Natalija Filipović, DVM, PhD (publications)

Members of the group:

Professor Ivica Grković, MD, PhD, founder and foremer head of laboratory (publications)
Associate professor Katarina Vukojević, MD, PhD (publications)
Ivan Agnić, MD, PhD (publications)
Ana Vuica, MD, PhD (publications)
Benjamin Benzon, MD, PhD
Vana Košta, MD, PhD

Danica Boban, MD, PhD student
Marija Jurić, MD, PhD student
Ivana Šolić, MD, PhD student
Marija Vitlov Uljević, PhD student
Martina Luetić, MD, PhD student
Edita Dražić-Maras, MD, PhD student
Ivan Brdar, MD, PhD student
Marjan Urlić, MD, PhD student
Leo Jerčić, DVM, PhD student
Igor Roje, MD, PhD student
Ivan Šustić, MD, PhD student
Diana Bajo, MD, PhD student
Josipa Domazet-Bugarin, MD, PhD student
Adela Arapović, MD, PhD student
Maja Dražić, MD, PhD student

Genia Kretzschmar, MD
Maximilian Grobe, MD
Silvia Dužević, MD

Our main goal is focused on the autonomic innervation,with particular accent on cardiac innervation; in physiological, as well as in pathological conditions of myocardial ischemic injury and/or metabolic diseases.


Urlić, Marjan, Urlić, Ivanka, Urlić, Hrvoje, Mašek, Tomislav, Benzon, Benjamin, Vitlov Uljević, Marija, Vukojević, Katarina, Filipović, Natalija (2020): Effects of Different n6/n3 PUFAs Dietary Ratio on Cardiac Diabetic Neuropathy. Nutrients 12: 2761.

Milardović, Ivana, Vitlov Uljević, MarijaVukojević, Katarina, Kostić, Sandra, Filipović, Natalija (2020): Renal expression of sigma 1 receptors in diabetic rats. Acta histochem. 122:151580.

Filipović, Natalija, Ivana Bočina, Ivana Restović, Maximilian GrobeGenia Kretzschmar, Nives Kević, Tomislav Mašek, Marija Vitlov UljevićMarija JurićKatarina Vukojević, Mirna Saraga-Babić, Ana Vuica (2020): Ultrastructural characterization of vitamin D receptors and metabolizing enzymes in the lipid droplets of the fatty liver in rat. Acta histochem. 122: 151502.

Luetić, MartinaVitlov Uljević, Marija, Mašek, Tomislav, Benzon, BenjaminVukojević, KatarinaFilipović, Natalija (2020): PUFAs supplementation affects the renal expression of pannexin 1 and connexins in diabetic kidney of rats. Histochem Cell Biol. 153: 165-175.

Vitlov Uljević, Marija, Starčević, Kristina, Mašek, Tomislav, Bočina, Ivana, Restović, Ivana, Kević, Nives, Racetin, Anita, Kretzschmar, GeniaGrobe, MaximilianVukojević, Katarina, Saraga-Babić, Mirna, Filipović, Natalija (2019): Dietary DHA/EPA supplementation ameliorates diabetic nephropathy by protecting from distal tubular cell damage. Cell and tissue research. 378: 301-317.

Jerčić, Leo, Kostić, Sandra, Vitlov Uljević, Marija, Vukušić Pušić, Tanja, Vukojević, Katarina, Filipović, Natalija (2019): Sigma-1 receptor expression in DRG neurons during a carrageenan-provoked inflammation. Anatomical record-advances in integrative anatomy and evolutionary biology.  302: 1620-1627. 

Vitlov Uljević, Marija, Bočina, Ivana, Restović, Ivana, Kunac, Nenad, Mašek, Tomislav; Kretzschmar, GeniaGrobe, Maximilian, Šarić, Mia, Vukojević, Katarina, Saraga-Babić, Mirna, Filipović, Natalija (2018): Reabsorption in the proximal tubuli – an ultrastructural evidence for a novel aspect of renal VEGF trafficking. Cell and tissue research. 374: 189-201

Grobe, Maximilian; Kretzschmar, Genia; Vuica, Ana; Filipović, Natalija (2018): Expression of VDR in the superior cervical ganglia of rats. Biotechnic & histochemistry. 93: 320-327
Agnić, IvanFilipović, NatalijaVukojević, Katarina, Saraga-Babić, Mirna, Grković, Ivica (2018): Isoflurane postconditioning influences dynamics of infarct healing in rats. Biotechnic & histochemistry. 93: 354-363

Baković, Marija, Filipović, Natalija, Ferhatović Hamzić, Lejla, Kunac, Nenad, Zdrilić, Elena, Vitlov Uljević, Marija, Kostić, Sandra, Puljak, Livia, Vukojević, Katarina (2018): Changes in neurofilament 200 and tyrosine hydroxylase expression in the cardiac innervation of diabetic rats during ageing. Cardiovascular pathology  32: 38-43

Jerić, Milka, Vukojević, KatarinaVuica, AnaFilipović, Natalija (2017): Diabetes mellitus influences the expression of NPY and VEGF in neurons of rat trigeminal ganglion. Neuropeptides 62: 57-64

Vuica, AnaKatarina Vukojević, Lejla Ferhatović Hamzić, Milka Jerić, Livia Puljak, Ivica GrkovićNatalija Filipović (2016): Expression pattern of CYP24 in liver during ageing in long-term diabetes. Acta Histochemica A Journal of Structural Biochemistry, Cell and Tissue Imaging 118: 486-495

Agnić, IvanNatalija FilipovićKatarina Vukojević,  Mirna Saraga-Babić, Marija VrdoljakIvica Grković (2015): Effects of isoflurane post-conditioning on chronic phase of ischemia-reperfusion heart injury in rats. Cardiovascular pathology 24: 94-101
Filipović, Natalija, Tomislav Mašek, Ivica Grković (2015): Expression of nestin in superior cervical ganglia of rats is influenced by gender and gonadectomy. Journal of chemical neuroanatomy 63: 6-12
Jerić, MilkaAna Vuica, Matija Borić, Livia Puljak, Antonia Jeličić Kadić, Ivica GrkovićNatalija Filipović (2015): Diabetes mellitus affects activity of calcium/calmodulin-dependent protein kinase II alpha in rat trigeminal ganglia. Journal of chemical neuroanatomy 64-65: 12-19

Vuica, Ana, Lejla Ferhatović Hamzić, Katarina VukojevićMilka Jerić, Livia Puljak, Ivica GrkovićNatalija Filipović (2015): Ageing and a long-term diabetes mellitus increase expression of 1 α-hydroxylase and vitamin D receptors in the rat liver. Experimental gerontology 72: 167-176
Agnić, IvanKatarina Vukojević, Mirna Saraga-Babić, Natalija FilipovićIvica Grković (2014): Isoflurane post-conditioning stimulates the proliferative phase of myocardial recovery in an ischemia-reperfusion model of heart injury in rats. Histology and histopathology 29: 89-99
Filipović, NatalijaMarija VrdoljakAna VuicaMilka Jerić, Antonia Jeličić Kadić, Toni Utrobičić, Tomislav Mašek, Ivica Grković (2014): Expression of PTHrP and PTH/PTHrP receptor 1 in the superior cervical ganglia of rats. Neuropeptides 48: 353-359
Filipović, Natalija, Leona Žuvan, Tomislav Mašek, Ružica Tokalić, Ivica Grković (2014): Gender and gonadectomy influence on neurons in superior cervical ganglia of sexually mature rats. Neuroscience letters 563: 55-60
Banožić, Adriana, Ivica Grković, Damir Sapunar, Livia Puljak (2014): Behavioral changes following experimentally-induced acute myocardial infarction in rats. International heart journal. 55: 169-177
Baković, Marija, Marina Jurić Paić, Elena Zdrilić, Katarina Vukojević, Lejla Ferhatović, Ana Marin, Natalija FilipovićIvica Grković, Livia Puljak (2013) Changes in cardiac innervation during maturation in long-term diabetes. Experimental gerontology. 48: 1473-1478
Filipović, Natalija, Lejla Ferhatović, Ivana Marelja, Livia Puljak, Ivica Grković (2013): Increased vitamin D receptor expression in dorsal root ganglia neurons of diabetic rats. Neuroscience letters 549: 140-145
Marinović Guić, Maja, Branka Runtić, Vana Košta, Jure Aljinović, Ivica Grković (2013): Age-related changes of neurochemically different subpopulations of cardiac spinal afferent neurons in rat. Experimental gerontology. 48: 774-777
Košta, Vana, Maja Marinović Guić, Jure Aljinović, Ana Čarić, Ivica Grković (2011): The influence of exercise on morphological and neurochemical properties of neurons in rat nodose ganglia. Neuroscience letters 490: 36-40
Aljinović, Jure, Katarina Vukojević, Vana Košta, Maja Marinović Guić, Mirna Saraga-Babić,  Ivica Grković (2010): Histological differences in healing following experimental transmural infarction in rats. Histology and histopathology. 25: 1507-1517
Košta, Vana, Maja Marinović Guić, Jure Aljinović, Damir Sapunar, Ivica Grković (2010): Immunohistochemical characteristics of neurons in nodose ganglia projecting to the different chambers of the rat heart. Autonomic neuroscience: basic & clinical 155: 33-38
Marinović Guić, Maja, Vana Košta, Jure Aljinović, Damir Sapunar, Ivica Grković (2010): Characterization of spinal afferent neurons projecting to different chambers of the rat heart. Neuroscience letters 469: 314-318

From the collection of microphotographs of the Laboratory:

Dopaminergic neurons in substantia nigra of rat. (G. Kretzschmar and M. Grobe)

Astrocytes (green; gfap) and microglia (red; iba1), in hippocampus of rat  (nuclei are stained blue). (G. Kretzschmar and M. Grobe)

Lipid droplets in renal proximal tubular cells, stained by Sudan-red method. (N. Filipović)

Myocardial infarction during healing. Nestin - marker for the immature cells (green), alpha smooth actin - aSMA (red), blue - nuclei. (N. Filipović)

Myocardial infarction during healing. Nestin - marker for the immature cells (green), alpha smooth actin - aSMA (red), blue - nuclei. (N. Filipović and M. Vrdoljak)

Superior cervical ganglion (SCG) of rat. Neuropeptide y (NPY) in neurons (green), calretinin in presynaptic terminals (red). (N. Filipović)

Pgp9.5 in neuronal fibres in myocardium of rat (green). (N. Filipović, M. Vrdoljak and D. Jakus)

Stellate cells in liver of rat - gfap immunoreactive (green),  nuclei are stained blue. (A. Vuica)

Neurofilament 200 kDa (red) in ventral horn of the spinal cord of the human embryo (9 weeks old)nuclei are stained blue. (N. Filipović)

PTH-receptors in membranes of rat cardiomyocytes (green)nuclei are stained blue. (N. Filipović)

Neurofilament 200 kDa (red) in trigeminal ganglion of rat. (N. Filipović)

Isolectin b4  (green) in trigeminal ganglion of rat. (M. Jerić)

CGRP (red) in neurons of trigeminal ganglion of rat. (N. Filipović)

s100 (green) in satellite cells of the rats SCG. (N. Filipović)

Choline acetyltransferase in presynaptic terminals of rats SCG (red). (N. Filipović)

NeuN in trigeminal ganglion of rat (N. Filipović)

Parasympathetic neurons in adrenal medulla of rat. In difference from the cromafine cells, they are not immunoreactive for tyrosine-hydroxylase (green), nuclei are stained blue.  (N. Filipović)

Receptors of advanced end glycation products (RAGE) in membranes of the liver cells (red), nuclei are stained blue. (N. Filipović)

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