Pathobiochemistry of glycoantigens

Research group:  PATHOBIOCHEMISTRY OF GLYCOANTIGENS
 

Research leader
Assoc.prof. Anita Markotić, PhD, scientific advisor
 
Members 
Members are from Department of Medical Chemistry and Biochemistry including  Tina Tičinović Kurir from Department of Pathophysiology and University Hospital Split.
1. Assist.prof. Vedrana Čikeš Čulić, PhD
2. Nikolina Režić Mužinić, MSc
3. Angela Mastelić, MSc
4. Sandra Dujić Bilušić, MSc
5. Assoc.prof. Tina Tičinović Kurir, MD, PhD
  
Research activities
Glycoantigens are the secondary gene products, that means their expression depends upon expression of specific glycosyltransferases which catalyse their synthesis. Glycophenotype change could be the cause as well as the consequence of certain physiological and pathophysiological conditions.


Projects 
„Pathobiochemistry of glycosphingolipid antigens“ 2007-2014. (project leader: Anita Markotić, supported by the Croatian Ministry of Science, Education and Sports, no. 216-2160133-0066)
 
Recent publications

1. Režić-Mužinić N, Mastelić A, Markotić A, Čikeš-Čulić V, Vuica-Ross M, Ross A, Barker D, Reynisson J. The effect of a phospholipase C gamma inhibitor on the proliferation and phenotype of Du145 prostate cancer cells. FEBS J 2014;281(Suppl. 1):507.
2. Čikeš Čulić V, Martinić R, Markotić A, Ljubković M,  Brešković T, Marinović J, Dujić Ž. Expression of Endothelial Selectin Ligands on Leukocytes Following Repeated Dives in SCUBA Divers.. Periodicum biologorum 2014:116:39-45.
3. Novak A, Režić Mužinić N, Cikeš Čulić V, Božić J, Tičinović Kurir T, Ferhatović L, Puljak L, Markotić A. Renal distribution of ganglioside GM3 in rat models of types 1 and 2 diabetes. J Physiol Biochem 2013;69:727-35.
4. Režić-Mužinić N, Cikeš-Čulić V, Božić J, Tičinović-Kurir T, Salamunić I, Markotić A. Hypercalcemia induces a proinflammatory phenotype in rat leukocytes and endothelial cells. J Physiol Biochem 2013;69:199-205.
5. Markic J, Jeroncic A, Polancec D, Bosnjak N, Markotic A, Mestrovic J, Culic VC. CD15s is a potential biomarker of serious bacterial infection in infants admitted to hospital. Eur J Pediatr. 2013;172:1363-9.
6. Đevenica D, Čikeš Čulić V, Vuica A, Markotić A. Biochemical, pathological and oncological relevance of Gb3Cer receptor. Med Oncol 2011;28:S675-84.

 
PhD theses 

1. Anela Novak. Ganglioside GM3 and its sphingolipid precursor expression in the muscle and kidney of rat models of diabetes mellitus type 1 and 2. Split: University of Split School of Medicine, 2013. Mentor: Tina Tičinović Kurir
2. Joško Markić. The Utility of Leukocyte CD15s, CD11b and CD64 Antigen Determination  in Diagnosis of Serious Bacterial Infection in Febrile Infants. Split: University of Split School of Medicine, 2013. Mentor: Vedrana Čikeš Čulić
3. Vedrana Čikeš Čulić.Immunochemical analyses of gangliosides in the liver of partially hepatectomized rats treated with hyperbaric oxygen. Zagreb: University of Zagreb Faculty of Pharmacy and Biochemistry, 2009. Mentor: Anita Markotić
4. Tina Tičinović Kurir. The effect of hyperbaric oxygenation upon rat liver regeneration: biochemical and immunohistochemical analysis. Split: University of Split School of Medicine, 2007. Mentor: Anita Markotić

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