Lorainne Tudor Car
Name: dr. sc. TUDOR CAR LORAINNE dr. med.
Thesis title: „INTEGRATING PREVENTION OF MOTHER-TO-CHILD HIV TRANSMISSION (PMTCT) PROGRAMMES WITH OTHER HEALTH SERVICES FOR PREVENTING HIV-INFECTION AND IMPROVING HIV OUTCOMES IN DEVELOPING COUNTRIES.“
Doctoral dissertation full text (pdf)
Mentor: prof. dr. sc. POLAŠEK OZREN
Qualifying research publications:
Tudor Car L, Van Velthoven M, Brusamento S, Elmoniry H, Car J, Majeed A, Atun R. Integrating prevention of mother-to-child HIV transmission (PMTCT) programmes with other health services for preventing HIV infection
and improving HIV outcomes in developing countries. Cochrane Database Syst
Rev 2011;(6):CD008741. PMID: 21678382
IF (JCR 2011) 5.912
Tudor Car L, Van Velthoven MH, Brusamento S, Elmoniry H, Car J,
Majeed A, Tugwell P, Welch V, Marusic A, Atun R. Integrating prevention of
mother-to-child HIV transmission programs to improve uptake: a systematic
review. PLOS One. 2012;7(4):e35268. PMID: 22558134
IF (JCR 2012) 3.730
Tudor Car L, Brusamento S, Elmoniry H, Van Velthoven M, Pape UJ,
Welch V, Tugwell P, Majeed A, Rudan I, Car J, Atun R. The uptake of
integrated perinatal prevention of mother-to-child HIV transmission programs
in low- and middle-income countries: a systematic review. Plos ONE
2013;8:e56550. PMID: 23483887
IF (JCR 2013) 3.534
Van Velthoven MH, Tudor Car L, Car J, Atun R. Telephone consultation
for improving health of people living with or at risk of HIV: a systematic
review. PLOS One 2012;7(5):e36105. PMID: 22615751
IF (JCR 2012) 3.730
Van-Velthoven MH, Tudor Car L, Gentry S, Car J. Telephone delivered
interventions for preventing HIV infection in HIV-negative persons. Cochrane
Database Syst Rev 2013;5:CD009190. PMID: 23728688
IF (JCR 2013) 5.939
Tudor Car L, Gentry S, van-Velthoven MH, Car J. Telephone
communication of HIV testing results for improving knowledge of HIV
infection status. Cochrane Database Syst Rev 2013;1:CD009192. PMID: 23440835
IF (JCR 2013) 5.939
Gentry S, van-Velthoven MH, Tudor Car L, Car J. Telephone delivered
interventions for reducing morbidity and mortality in people with HIV
infection. Cochrane Database Syst Rev 2013 31;5:CD009189. PMID: 23728687
IF (JCR 2013) 5.939
Brusamento S, Ghanotakis E, Tudor Car L. Male involvement for
increasing the effectiveness of prevention of mother-to-child HIV
transmission (PMTCT) programmes. Cochrane Database Syst Rev Cochrane
Database Syst Rev 2012;(10):CD009468. PMID: 23076959
IF (JCR 2012) 5.785
Summary:
Integrating prevention of mother-to-child HIV transmission (PMTCT) programmes
with other health services for preventing HIV infection and improving HIV outcomes in
developing countries (Cochrane systematic review)
Background
Mother-to-child transmission of HIV (MTCT) is responsible for more than 90% of HIV
infections in children. In high-income countries, the MTCT rate is less than 1% through
perinatal prevention of mother-to-child HIV transmission (PMTCT) interventions.
Objectives
To assess the effect of integration of PMTCT measures with other healthcare services on
uptake compared to stand-alone or partially integrated PMTCT interventions in low- and
middle-income countries.
Methodology
Two authors independently ran the searches, selected studies, assessed methodological
quality, and extracted data.
Main results
One cluster-randomised trial was included. It compared mother-infant Nevirapine coverage at
labour ward between intervention clinics implementing rapid HIV testing and structured
Nevirapine adherence assessment and control clinics implementing informal assessment of
Nevirapine adherence. The study showed that the probability of Nevirapine coverage of
mothers and infants in the intervention arm compared to control arm increased from 0.89 at
baseline to 1.22 during the intervention period (RR 1.37, bootstrapped 95% CI, 1.041.77).
Conclusions
The included study showed significant improvement in coverage but only addressed the
labour ward aspect of PMTCT programme. This weak evidence base does not allow any
inferences regarding the effectiveness of integration of other PMTCT interventions, in other
countries or contexts. Further research is urgently needed.
Doctoral dissertation appraisal reports (pdf)
Doctoral dissertation topic proposals (pdf)
Doctoral dissertation topic appraisals (pdf)
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