Laboratory for cancer research

Laboratory for cancer research

Laboratory for cancer research

Laboratorij za istraživanje raka
Head of the laboratory 

Prof. Janoš Terzić

Research interests
1) Our research interests are focused on understanding molecular and cellular mechanisms of colon and bladder cancer development. We use AOM/DSS based mice model for inflammation related colon cancer model, as well as BBN model for bladder cancer. In our work we use knock-out and conditional knock out mice models and we collect and study human tumor samples in order to parallel findings on animal models with actual human disorder. In addition to this, we perform basic molecular biology studies on proteins involved in cancer pathogenesis.
2) We investigate the proteins important in DNA damage repair. If mutated, damaged and malfunctioning, these proteins can lead to tumorigenesis.
3) We study the cellular process of autophagy. It is one of the protective mechanisms by which cells remove their harmful components. Given its role in removing these substances, autophagy actively slows aging, prevents tumor formation as well as has an impact on inflammatory and neurodegenerative diseases. Of particular interest is its role in tumor development, since it was shown that errors in the process of autophagy often directly influence development of the disease.
Active projects
HRZZ - The role of autophagy receptors in selective removal of mitochondria - AutoMito
Project leader Prof. Ivana Novak Nakir, PhD
HRZZ - Role of inflammation in bladder cancer pathogenesis - iBC
Project leader Prof. Janoš Terzić, MD, PhD
HRZZ - The role of Spartan in DNA replication - SprtnRep
Project leader Prof. Ivana Marinović Terzić, MD, PhD
Compartmentalized ErbB signaling 
Project leader: doc. dr. sc. Jasminka Omerović

Group members
Janoš Terzić, Prof, PhD., group leader
Ivan Đikić, Prof, PhD., Goethe University, Frankfurt, Germany
Ivana Marinović Terzić, Prof, PhD.
Ivana Novak Nakir, Prof, PhD.
Jasminka Omerović, Assist. Prof, PhD.
Jelena Korać Prlić, Assist. Prof, PhD. 
Sandra Vujević, bacc. med. lab. diag, Lab manager
Mija Marinković, mag. biol. mol., PhD student
Blanka Rojemag. educ. biol. et chem., PhD student
Anja Ančić
mag. biol. mol., PhD student
Maria Bošković, mag. biol. mol., PhD student
Ejazul Hague, PhD, postdoctoral fellow

Martina Paradžik Šimunović, MD, PhD student
Tonči Ivanišević

Photo album
Prof. Boris Maček, PhD., Proteome Center Tübingen, Germany 
Prof. Nathan Brady,PhD., DKFZ, Heidelberg, Germany
Prof. Kristijan Ramadan,PhD., University of Oxford, UK
Davor Lessel, MD, University of Hamburg, Germany
Prof. Dimitri Krainc, PhD., Northwestern University, Chicago, USA
Assist. Prof Viljemka Bučević Popović, PhD ,  PMF Split, Croatia
Matilda Šprung,PhD., PMF Split, Croatia
Prof. Sergei Grivennikov, PhD., Fox Chase Cancer Center, Philadelphia, USA

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